Genetic transformation studies. II. Radiation sensitivity of halogen labeled DNA
Journal Article
·
· Biochemical and Biophysical Research Communications
The replacement of the methyl group in the 5-position of the thymine molecule by halogen atoms produces a biologically functional analog which can be substituted for thymine in the desoxyribonucleic acid molecule. Tests were made of the sensitivity of this labeled desoxyribonucleic acid to ultraviolet light and x radiation, and the results were compared to the sensitivity of intact cells. Finally, results indicate that desoxyribonucleic acid is the most radiosensitive cell component and thus the principal target of lethal radiation effects.
- Research Organization:
- Univ. of Wisconsin, Madison
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-15-014125
- OSTI ID:
- 4063787
- Journal Information:
- Biochemical and Biophysical Research Communications, Journal Name: Biochemical and Biophysical Research Communications Journal Issue: 4 Vol. 4; ISSN 0006-291X
- Publisher:
- Elsevier
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
Similar Records
MOLECULAR RADIOBIOLOGY OF HUMAN CELL LINES. I. COMPARATIVE SENSITIVITY TO X-RAYS AND ULTRAVIOLET LIGHT OF CELLS CONTAINING HALOGEN-SUBSTITUTED DNA
EFFECT OF OXYGEN IN MAMMALIAN CELLS SENSITIZED TO RADIATION BY INCORPORATION OF 5-BROMODEOXYURIDINE INTO THE DNA
Effects of ‘Visible’ Light on 5-Bromouracil-labelled DNA
Journal Article
·
Thu Mar 23 23:00:00 EST 1961
· Biochem. Biophys. Research Communs.
·
OSTI ID:4067685
EFFECT OF OXYGEN IN MAMMALIAN CELLS SENSITIZED TO RADIATION BY INCORPORATION OF 5-BROMODEOXYURIDINE INTO THE DNA
Journal Article
·
Fri Apr 19 23:00:00 EST 1963
· Nature
·
OSTI ID:4714966
Effects of ‘Visible’ Light on 5-Bromouracil-labelled DNA
Journal Article
·
Fri Nov 16 23:00:00 EST 1962
· Nature (London)
·
OSTI ID:4754728