THE EFFECT OF BODY TEMPERATURE ON THE SENSITIVITY OF THE HAEMOPOIETIC TISSUES OF MICE TO X-IRRADIATION
The effect of x-irradiation on the hemopoietic tissues of mice while they are at body temperathres of 15 deg C is described. Histological examination of the spleen and femoral bone marrow revealed no differences between groups of animals irradiated at body temperatures of 15 deg C and those irradiated at normal body temperatures and then cooled to 15 deg C over the dose range 0 to 950 r. The total peripheralleukocyte counts were compared with those obtained in previous experiments when animals were irradiated at body temperatures of l deg C and at normal body temperatures. Statistical analysis shows that on the evidence of leukocyte counts five days after irradiation, exposure of animals to x rays while they are at body temperatures of 15 deg C affords slight protection to the hemopoietic tissues, which is much less than the protection provided at body temperatures of l deg C when the animals are severely hypoxic. Cooling to 15 deg C after irradiation affords no detected radioprotection. (auth)
- Research Organization:
- National Inst. for Medical Research, London
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-15-014134
- OSTI ID:
- 4063656
- Journal Information:
- Intern. J. Radiation Biol., Journal Name: Intern. J. Radiation Biol. Vol. Vol: 3
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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