COMBINED ACTION OF CIGARETTE TAR AND BETA RADIATION ON MICE

Journal Article · Wed Mar 01 04:00:00 EST 1961 · Cancer

DOI:https://doi.org/10.1002/1097-0142(196103/04)14:2<344::AID-CNCR2820140214>3.0.CO;2-M· OSTI ID:4062883

Cowdry, E V; Croninger, A; Solaric, S; Suntzeff, V

Periodic beta irradiation from Sr/sup 90/ to distributed areas of the skin of mice in total doses of as much as 20,800 rep when applied concurrently with cigarette tar produces an additive effect in the production of epidermal carcinogenesis. There is no svidence of a synergistic effect between the two carcinogens. Radiation alone has little carcinogenic effect on the skin as applied under the conditions described. Groups with greater percentuges of malignant skin tumors have had shorter lives than those with smaller percentuges or without skin tumors. The percentage of tumors of the lung, leukemia, mamary- gland carcinoma, and hepatoma was greater in groups in which the percentage of malignant tumors of the skin was low. (auth)

• Research Organization: Washington Univ. School of Medicine, St. Louis
• Sponsoring Organization: USDOE
• NSA Number: NSA-15-012738
• OSTI ID: 4062883
• Journal Information: Cancer, Journal Name: Cancer Vol. Vol: 14
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BETA PARTICLES
BIOLOGY AND MEDICINE
BITUMENS
CANCER
CARCINOGENESIS
GLANDS
LEUKEMIA
LIFETIME
LIVER
MICE
RADIATION EFFECTS
SKIN
STRONTIUM 90