COMBINED ACTION OF CIGARETTE TAR AND BETA RADIATION ON MICE
Periodic beta irradiation from Sr/sup 90/ to distributed areas of the skin of mice in total doses of as much as 20,800 rep when applied concurrently with cigarette tar produces an additive effect in the production of epidermal carcinogenesis. There is no svidence of a synergistic effect between the two carcinogens. Radiation alone has little carcinogenic effect on the skin as applied under the conditions described. Groups with greater percentuges of malignant skin tumors have had shorter lives than those with smaller percentuges or without skin tumors. The percentage of tumors of the lung, leukemia, mamary- gland carcinoma, and hepatoma was greater in groups in which the percentage of malignant tumors of the skin was low. (auth)
- Research Organization:
- Washington Univ. School of Medicine, St. Louis
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-15-012738
- OSTI ID:
- 4062883
- Journal Information:
- Cancer, Journal Name: Cancer Vol. Vol: 14
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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