THE METABOLISM OF VINCA ALKALOIDS. PART I. PREPARATION OF TRITIATED VINBLASTINE THE RATE OF URINARY EXCRETION OF RADIOACTIVITY BY RATS RECEIVING THE COMPOUND

Journal Article · Tue Dec 31 23:00:00 EST 1963 · Canadian Journal of Physiology and Pharmacology (Canada) Continues in part Can. J. Biochem. Physiol.

DOI:https://doi.org/10.1139/y64-001· OSTI ID:4062860

Beer, C T; Wilson, M L; Bell, J

The preparation of tritium-labeled vinblastine by the Wilzbach irradiation method is described. Tritiated dihydrovinblastine was concurrently formed and could not be detected or separated from tritiated vinblastine by previously available methods. It is now found that tritiated vinblastine can be freed from the contaminating dihydro compound by chromatography on cellulose phosphate. The rate of urinary excretion of radioactivity by rats given injections of the purified alkaloid was studied. About 5% of the dose radioactivity is excreted in the urine collected in the 12-hr period after injection; thereafter only very minor amounts of radioactivity are eliminated by this route. (auth)

• Research Organization: Univ. of British Columbia, Vancouver
• Sponsoring Organization: USDOE
• NSA Number: NSA-18-015790
• OSTI ID: 4062860
• Journal Information: Canadian Journal of Physiology and Pharmacology (Canada) Continues in part Can. J. Biochem. Physiol., Journal Name: Canadian Journal of Physiology and Pharmacology (Canada) Continues in part Can. J. Biochem. Physiol. Vol. Vol: 42; ISSN CJPPA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ALKALOIDS
BIOLOGY AND MEDICINE
CELLULOSE
CHROMATOGRAPHY
IMPURITIES
LABELLED COMPOUNDS
METABOLISM
PHOSPHATES
PREPARATION
RADIOACTIVITY
RATS
TRITIUM
URINE