Neonatal changes in renal blood flow distribution in puppies

Journal Article · Thu May 01 04:00:00 EDT 1975 · Am. J. Physiol., v. 228, no. 5, pp. 1453-1461

OSTI ID:4061018

Aschinberg, L C; Goldsmith, D I; Olbing, H; Spitzer, A; Edelmann, Jr, C M; Blaufox, M D

The intrarenal distribution of blood flow was studied in 31 newborn mongrel puppies from 18 h to 70 days using xenon washout and krypton autoradiography. Mean renal blood flow increased from 0.39 +- 0.05 ml/g per min (SE) the 1st wk to 2.06 +- 0.12 ml/g per min at 6 wk. During the 1st wk of life the renal cortex was perfused homogeneously at 0.88 +- 0.19 ml/g min (SE) and accounted for 35 +- 4 percent of the renal blood flow. During the 2nd wk a narrow, rapidly perfused zone of outer cortex was identified which was perfused at 3.35 +- 0.26 ml/g per min, received 19.53 +- 5.05 percent of the total renal blood flow, and represented 15 +- 4 percent of the mass of the total cortex. The inner cortex and outer medulla at this time received 53.40 +- 4.12 percent of the flow at 1.07 +- 0.08 ml/g per min. Outer cortical flow increased with age reaching adult values by about 6 to 10 wk when the rapidly perfused area represented 40 +- 8 percent of the cortex. These changes are parallel to the results of previously reported studies with microspheres in newborn puppies and are compatible with the well-established maturational changes noted in neonates of several species. They represent the first gas-washout studies in animals during the first 6 wk of life. (auth)

• Research Organization: Albert Einstein Coll. of Medicine, Bronx, NY
• NSA Number: NSA-33-029857
• OSTI ID: 4061018
• Journal Information: Am. J. Physiol., v. 228, no. 5, pp. 1453-1461, Journal Name: Am. J. Physiol., v. 228, no. 5, pp. 1453-1461; ISSN AJPHA
• Country of Publication: United States
• Language: English

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XENON 133