INCORPORATION OF RADIOACTIVELY LABELED PHOSPHATE AS AN INDICATION OF METABOLIC CONDITIONS IN THE LIVER

Journal Article · Sun Mar 01 04:00:00 EST 1964 · Atompraxis (West Germany) Incorporated in Kerntechnik

OSTI ID:4060319

Boquoi, E

Various chemical and biological factors cause an increase in uptake and incorporation of radioactively labeled phosphate in the rat liver after irtraperitoneal injection. This effect was shown by groups of heterogeneous substances: cytistatic substances (N-Lost Mitomen, Endoxan, TEM, E/sub 39/); substances causing liver damage (CCl/sub 4/, allyl formate, and ethionine, as well as the anesthetic avertin); lyophilized liver cells and organ homogenates; total-body x irradiation; and partial (2/3) hepatectomy. Morphological damage to the liver was demonstrable under a light microscope only in regard to those substances known to cause hepatic damage: CCl/sup 4/, allyl formate, and ethionine. The total incorporation of phosphate in high-molecular substances, and a corresponding increase in this process, is proportional to the phosphate uptake. The increase in phosphate uptake is possibly the result of varying effective mechanisms, with varying points of attack. (auth)

• Research Organization: Universitat, Munich
• NSA Number: NSA-18-017422
• OSTI ID: 4060319
• Journal Information: Atompraxis (West Germany) Incorporated in Kerntechnik, Journal Name: Atompraxis (West Germany) Incorporated in Kerntechnik Vol. Vol: 10; ISSN ATPXA
• Country of Publication: Country unknown/Code not available
• Language: German

Related Subjects

ANESTHETICS
ANIMAL CELLS
ANTIMITOTIC DRUGS
BIOCHEMISTRY
BIOLOGY
BIOLOGY AND MEDICINE
BODY
CARBON TETRACHLORIDE
CHEMICAL REACTIONS
CYTOLOGY
DIFFUSION
DISEASES
DRUGS
ENDOXAN
ETHIONINE
FORMIC ACID
INTESTINE
IRRADIATION
LABELLED COMPOUNDS
LIVER
METABOLISM
MICROSCOPY
MOLECULES
ORGANIC SULFUR COMPOUNDS
PHOSPHATES
RADIOISOTOPES
RATS
REACTION KINETICS
SURGERY
SUSPENSIONS
TISSUES
TOXICITY
VARIATIONS
X RADIATION