Uptake kinetics of relatively insoluble particles by tracheobronchial lymph nodes
Conference
·
OSTI ID:4059784
Tracheobronchial lymph nodes accumulate a portion of material deposited in the deep lung following inhalation of relatively insoluble particles. Experiments involving a variety of compounds, inhaled singly or repeatedly, indicate that the kinetics of lymph node uptake are fairly independent of particle characteristics and mammalian species. The buildup per unit weight of nodal tissue compared with that of lung tissue, with time, can be represented by a linear logarithmic function. However, since the scatter in experimental points may be large at any given time after inhalation exposure, a number of different kinetic descriptions of uptake can be derived. The logarithmic pattern of accumulation can be approximated over an extended time range (several years) by use of a combination of first-order kinetics of loss from the lung and of buildup in lymph nodes, but it is recognized that the processes are much more complicated than this treatment would indicate. Clearance (loss) from the lymph nodes is not well defined, but this aspect is discussed in light of the kinetic models presented. (auth)
- Research Organization:
- Los Alamos Scientific Lab., NM; Battelle Pacific Northwest Labs., Richland, Wash. (USA); USAEC Division of Biomedical and Environmental Research, Washington, D.C.
- NSA Number:
- NSA-33-023582
- OSTI ID:
- 4059784
- Report Number(s):
- CONF-740930--
- Country of Publication:
- United States
- Language:
- English
Similar Records
Effect of $sup 144$Ce inhaled in fused-clay particles on the tracheobronchial lymph nodes
Translocation of particles from lung lobes or the peritoneal cavity to regional lymph nodes in beagle dogs
Translocation of particles to the pleural space and tracheobronchial lymph nodes following lung deposition
Conference
·
Wed Dec 31 23:00:00 EST 1975
·
OSTI ID:4052535
Translocation of particles from lung lobes or the peritoneal cavity to regional lymph nodes in beagle dogs
Journal Article
·
Fri Dec 31 23:00:00 EST 1982
· J. Toxicol. Environ. Health; (United States)
·
OSTI ID:6051746
Translocation of particles to the pleural space and tracheobronchial lymph nodes following lung deposition
Conference
·
Mon Dec 31 23:00:00 EST 1984
·
OSTI ID:5375760