Translocation of particles from lung lobes or the peritoneal cavity to regional lymph nodes in beagle dogs

Journal Article · Sat Jan 01 04:00:00 EST 1983 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398309530378· OSTI ID:6051746

Snipes, M B; Muggenburg, B A; Bice, D E

Knowing the clearance pathways from the lung for inhaled materials is important to our understanding of the kinetics of particle clearance from the lung and other defense mechanisms, such as development of immune reaction to inhaled antigens. To determine the pathways and amounts of particles translocated to regional lymph nodes, radiolabeled fused aluminosilicate particles were instilled into specific lung lobes or injected into the peritoneal cavity of beagle dogs and the dogs were necropsied 34, 182, or 365 d later. Individual lung lobes cleared particles to one of two lymph nodes, and specific lymph nodes accumulated particles from one to three lung lobes. Lymph nodes that collected particles from the lung included the left mediastinal node, left tracheobronchial lymph node (TBLN), right TBLN, left middle TBLN, and right middle TBLN. The destinations for translocated particles were primarily the nodes proximate to the tracheal bifurcation. Particles injected into the peritoneal cavity were translocated mainly to mesenteric lymph nodes and left sternal and right sternal lymph nodes, with a small percentage of the particles going also to the left TBLN. 17 references, 3 figures, 2 tables.

• Research Organization: Inhalation Toxicology Research Inst., Albuquerque, NM
• DOE Contract Number: AC04-76EV01013
• OSTI ID: 6051746
• Journal Information: J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 11; ISSN JTEHD
• Country of Publication: United States
• Language: English

Related Subjects

551001 -- Physiological Systems-- Tracer Techniques
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL ISOTOPES
ALUMINIUM COMPOUNDS
ALUMINIUM SILICATES
ANIMALS
ANTIGENS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL PATHWAYS
BODY
CESIUM 134
CESIUM ISOTOPES
CLEARANCE
DOGS
EXCRETION
HOURS LIVING RADIOISOTOPES
IMMUNE REACTIONS
INHALATION
INTAKE
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
LUNG CLEARANCE
LUNGS
LYMPH NODES
LYMPHATIC SYSTEM
MAMMALS
MEMBRANES
NUCLEI
ODD-ODD NUCLEI
ORGANS
OXYGEN COMPOUNDS
PARTICLES
PARTICULATES
PERITONEUM
RADIOISOTOPES
RESPIRATORY SYSTEM
RETENTION
SEROUS MEMBRANES
SILICATES
SILICON COMPOUNDS
TRACER TECHNIQUES
TRANSLOCATION
VERTEBRATES
YEARS LIVING RADIOISOTOPES