Comparison of $sup 18$F and /sup 99m/Tc-polyphosphate in orthopedic bone scintigraphy

Journal Article · Sun Feb 01 04:00:00 EST 1976 · J. Nucl. Med., v. 17, no. 2, pp. 98-103

OSTI ID:4059380

Heerfordt, J; Vistisen, L; Bohr, H

To compare /sup 99m/Tc-polyphosphate and $sup 18$F for use in orthopedics, 79 patients were examined with both. Fifty cases were suitable for analysis. While the extraskeletal uptake of $sup 18$F was found to be negligible, /sup 99m/Tc-polyphosphate may accumulate considerably in pathologic soft tissue, e.g., in soft-tissue tumors and in inflamed synovial tissue. This soft-tissue Tc accumulation may obscure the osseous uptake, notably in the examination of joint regions, commonly the regions of interest in orthopedics. After simultaneous administration of both agents, quantitative measurements were performed on specimens of bone and synovial tissue from diseased joints in human patients and in rabbits. The uptake of /sup 99m/Tc-polyphosphate in synovial tissue was shown to be about seven times that of $sup 18$F, while their uptakes in bone were equal. In short, /sup 99m/Tc-polyphosphate, a valuable tracer in general, is hardly the agent of choice in orthopedics. (auth)

• Research Organization: Niels Bohr Inst., Copenhagen
• NSA Number: NSA-33-023645
• OSTI ID: 4059380
• Journal Information: J. Nucl. Med., v. 17, no. 2, pp. 98-103, Journal Name: J. Nucl. Med., v. 17, no. 2, pp. 98-103; ISSN JNMEA
• Country of Publication: United States
• Language: English

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