PRESENCE OF DONOR SPECIFIC $gamma$-GLOBULINS IN SERA OF ALLOGENEIC MOUSE RADIATION CHIMERAS
Young adult DBA/2 mice received a single whole-body x ray exposure of 840 rad followed by an intravenous injection of 8 x 10/sup 6/ bone marrow cells from normal (C3H x genic) chimeras, i.e., DBA/2 mice which received 840 rad plus an injection of 8 x 10/sup 6/ DBA/2 marrow cells. Blood serum from these chimeras was collected at times up to 9 months postirradiation, and analyzed for total gamma -globulin levels and for specific donor or host type gamma - globulin isoantigens. Marrow-donor type gamma -globulins (Igal) were found in the serum of the aflogeneic chimeras at various times up to 9 months after irradiation. By contrast, the sera from the syngeneic chimeras were negative for Igal gamma globulin, and showed high levels of Iga3 gamma -globulin, the DBA/2 type. It was shown also that the allogeneic chimeras were specifically tolerant to appropriate skin homografts; whereas, the syngeneic chimeras rejected both A- strain skin grafts and (C3H x DBA/2)F/sub 1/ skin grafts. (auth)
- Research Organization:
- Naval Radiological Defense Lab., San Francisco
- NSA Number:
- NSA-18-017411
- OSTI ID:
- 4058985
- Report Number(s):
- USNRDL-TR-709; AD-432416
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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