THE NATURE OF THE RADIATION-INDUCED LESION OF THE ELECTRON TRANSPORT CHAIN OF THYMUS MITOCHONDRIA
Mechanisms of the electron transfer reaction and the nature of the soluble factor released by irradiation were studied in thymocyte mitochondria. The effects of oxygen and cyanide on the succinic-2-p-iodophenyl-3-p-nitrophenyl- 5-phenylmonotetrazolium chloride (succinic-INT) reductase activity was measured in irradiated thymus homogenates; and succinic dehydrogenase, ubiquinone, and flavin cortents were measured in normal and irradiated (800 rads) thymus preparations. No reduction in the flavin content was found showing that dehydrogenase is not lost from thymus mitochondria following irradiation. Chemical properties of the soluble cofactor are cited. It is concluded that the coupling factor is likely a protein which is labilized from the mitochondria by irradiation. (H.M.G.)
- Research Organization:
- Defence Research Chemical Labs., Ottawa
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-18-017503
- OSTI ID:
- 4058328
- Journal Information:
- Canadian Journal of Biochemistry (Canada) Continues in part Can. J. Biochem. Physiol., Vol. Vol: 42; Other Information: Orig. Receipt Date: 31-DEC-64
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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Related Subjects
ANIMAL CELLS
AROMATICS
BIOCHEMISTRY
CATALYSIS
CHEMICAL REACTIONS
CHLORIDES
CYANIDES
CYTOLOGY
DECOMPOSITION
DEHYDROGENASES
DETECTION
ENZYMES
FLAVINS
IRRADIATION
MEASURED VALUES
MITOCHONDRIA
ORGANIC IODINE COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXIDATION
OXYGEN
PHENYL RADICALS
PIGMENTS
PROTEINS
QUINONES
RADIATION DOSES
RADIATION EFFECTS
RADIATION INJURIES
REACTION KINETICS
REDUCTASES
REDUCTION
SOLUBILITY
STANDARDS
SUCCINIC ACID
SUSPENSIONS
THYMOCYTES
THYMUS
VARIATIONS