LEUKEMOGENIC ACTIVITY OF CELL-FREE FILTRATES FROM RADIATION-INDUCED LEUKEMIA OF RF MICE

Journal Article · Sat Dec 01 04:00:00 EST 1962 · Nippon Ketsueki Gakkai Zasshi (Japan)

OSTI ID:4057085

Hiraki, K; Irino, S; Sota, S; Ikejiri, K

The incidence of leukemia in RF mice exposed to a single whole-body x irradiation dose of 350 r was 41 (77.4%) out of 53 animals. Of these 41, 20 developed the thymic type and other 20 the nonthymic type of lymphocytic leukemia, while only one developed myelogenous leukemia. Cell-free filtrates from these leukemic RF mice which were exposed to a single whole-body dose of x irradiation were inoculated in newborn mice of the same strain (less than 16 hr old). Two (16.7%) of the 12 inoculated animals developed leukemia on the 357th and 374th days, respectively, after inoculation. Inoculation of the cell-free filtrates from normal mice in the newborn mice of the same strain did not produce leukemia and not one of the nonirradiated mice developed leukemia. The possible role of a virus in the induction of leukemia by x irradiation is discussed. (BBB)

• Research Organization: Okayama Univ., Japan
• NSA Number: NSA-18-017561
• OSTI ID: 4057085
• Journal Information: Nippon Ketsueki Gakkai Zasshi (Japan), Journal Name: Nippon Ketsueki Gakkai Zasshi (Japan) Vol. Vol: 25; ISSN NKGZA
• Country of Publication: Country unknown/Code not available
• Language: Japanese

Related Subjects

AGE
BIOLOGY AND MEDICINE
BLOOD CELLS
BODY
CARCINOGENESIS
IRRADIATION
LEUKEMIA
LYMPHOCYTES
MICE
RADIATION DOSES
RADIATION EFFECTS
RADIATION SICKNESS
SENSITIVITY
THYMUS
TRANSPLANTS
VIRUSES