CLINICAL AND RADIOLOGICAL FINDINGS IN THOROTRAST INJURIES (in German)
The long physical and biological half life of /sup 232/Th and the dense ionization produced by its alpha particles within the reticuloendothelial tissue in which the colloidal ThO/sub 2/ accumulates produce severe radiation injuries. The latert period for appearance of injury in man varies from 11 to 24 yr. Clinical symptoms of Thorotrast injuries have been recentiy observed in five patients. Skin measuremerts of radioactivity demonstrated the presence of Thorotrast in liver, spleen, and bone marrow. So many factors affect these measuremerts that it is not possible to estimate accurately the actual amounts of Thorotrast deposited, but it has been calculnted that with a dose of 75 ml the radiation dose to liver is between 700 and 15,000 r over a period of 50 yr. For this same period the total radiation dose in bone marrow may be approximates 350 r. Of the total dose to the reticuloendothelial system liver receives from 71 to 73%, spleen from 7 to 17%, and bone marrow from 6 to 10%. One characteristic injury frequertly observed is the formation of granulomas (thorotrastomas) within the reticuloendothelial system thnt, depending on their location, can cause tracheal or esophageal stenosis, fistulas, vocal cord paralysis, or cerebral hypoxia. Blood changes, such as thrombocytopenla, slight leucopenia, appearance of large monocytes, and a relative aplastic myelodepressant effect, often appear. Liver thmors have been reported often, but in the patients studied here none were observed. One major late effect is appearance of fibrosis of the supportive tissue of the reticuloendothelial system that is often followed by damage to the tissue parenchyma. Many angiographic studies were performed with Thorotrast during the last war, and many patierts with injuries from this agent will probably be observed in the years coming. (BBB)
- Research Organization:
- I Medizinischen Klinik der Medizinischen Klinik der Medizinischen Akademie, Duesseldorf
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-18-017512
- OSTI ID:
- 4056681
- Journal Information:
- Deut. Med. Wochschr., Journal Name: Deut. Med. Wochschr. Vol. Vol: 88
- Country of Publication:
- Country unknown/Code not available
- Language:
- German
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Related Subjects
ANEMIA
ANIMAL CELLS
BIOLOGY
BIOLOGY AND MEDICINE
BLOOD CELLS
BONE MARROW
CARCINOGENESIS
COLLOIDS
DEPOSITS
DISEASES
GRANULOMAS
HALF- LIFE
IONIZATION
LEUCOCYTES
LIVER
LYMPH SYSTEM
MAN
MEASURED VALUES
MEDICINE
MONOCYTES
NUMERICALS
PLATELETS
QUANTITATIVE ANALYSIS
RADIATION DOSES
RADIATION INJURIES
RADIOACTIVITY
RETICULOENDOTHELIAL SYSTEM
SKIN
SPLEEN
STANDARDS
THORIUM 232
THORIUM OXIDES
THOROTRAST
TISSUES
TUMORS
VARIATIONS