Lymph transport of soluble and insoluble plutonium
Conference
·
OSTI ID:4052449
The uptake and transport mechanisms of soluble [Pu(NO$sub 3$$)$$sub 4$] and insoluble (polydispersed PuO$sub 2$) plutonium were studied in afferent and efferent lymph from the popliteal lymph nodes of dogs after simulated-wound exposures. Lymph was partitioned into acellular and cellular fractions. Plutonium nitrate concentration was higher in the acellular fraction of both afferent lymph and efferent lymph than in the cellular fraction, whereas the polydispersed PuO$sub 2$ concentration was higher in the cellular fraction at the end of the collection period. Discontinuous-gel, isoelectric-focusing-gel, and cellulose acetate strip electrophoresis indicated that transferrin and albumin were the two principal proteins transporting plutonium in the acellular fraction of both afferent and efferent lymph. (auth)
- Research Organization:
- Colorado State Univ., Fort Collins; Battelle Pacific Northwest Labs., Richland, Wash. (USA); USAEC Division of Biomedical and Environmental Research, Washington, D.C.
- NSA Number:
- NSA-33-023589
- OSTI ID:
- 4052449
- Report Number(s):
- CONF-740930--
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
*LYMPH NODES-- RADIONUCLIDE KINETICS
*LYMPHATIC SYSTEM-- RADIONUCLIDE KINETICS
*PLUTONIUM-- UPTAKE
560172* --Biomedical Sciences
Applied Studies--Radiation Effects--Nuclide Kinetics & Toxicology--Animals
ALBUMINS
BEAGLES
N48720* --Life Sciences--Nuclide Kinetics & Toxicology-- Animals
PLUTONIUM NITRATES
PLUTONIUM OXIDES
TRANSFERRIN
*LYMPHATIC SYSTEM-- RADIONUCLIDE KINETICS
*PLUTONIUM-- UPTAKE
560172* --Biomedical Sciences
Applied Studies--Radiation Effects--Nuclide Kinetics & Toxicology--Animals
ALBUMINS
BEAGLES
N48720* --Life Sciences--Nuclide Kinetics & Toxicology-- Animals
PLUTONIUM NITRATES
PLUTONIUM OXIDES
TRANSFERRIN