Translocation dynamics of Pu(NO$sub 3$$)$$sub 4$ and PuO$sub 2$ from puncture wounds to lymph nodes and major organs of beagles

Conference · Thu Jan 01 04:00:00 EST 1976

OSTI ID:4059718

Bistline, R W; Lebel, J L; Dagle, G E

The translocation dynamics of plutonium and americium from simulated puncture wounds in the paws of beagle dogs following contamination with Pu(NO$sub 3$$)$$sub 4$ and high-fired PuO$sub 2$ was studied. Fractions of initial implant transported to the first major lymph node and to major body organs were measured with in vivo counting equipment and by radiochemical analysis of tissue material collected at necropsy. Samples were obtained from serial necropsies ranging from 2 weeks to 1 year after implant. The difference in lymph node and organ- accumulation dynamics between the two chemical forms and the effects of diethylenetriaminepentaacetate (DTPA) chelation treatment are presented. Active mechanisms to transport plutonium to and from the lymph system appear to exist. Equations for buildup in the lymph nodes and organs are included. The data suggest a buildup in the lymph node to a maximum, followed by a long negative slope, and a possible dose-rate effect from Pu(NO$sub 3$$)$$sub 4$ in lymph nodes. (auth)

• Research Organization: Colorado State Univ., Fort Collins; Battelle Pacific Northwest Labs., Richland, Wash. (USA); USAEC Division of Biomedical and Environmental Research, Washington, D.C.
• NSA Number: NSA-33-023588
• OSTI ID: 4059718
• Report Number(s): CONF-740930--
• Country of Publication: United States
• Language: English

Related Subjects

*LYMPH NODES-- RADIONUCLIDE KINETICS
*LYMPHATIC SYSTEM-- RADIONUCLIDE KINETICS
*PLUTONIUM-- UPTAKE
560172* --Biomedical Sciences
Applied Studies--Radiation Effects--Nuclide Kinetics & Toxicology--Animals
BEAGLES
COMPARATIVE EVALUATIONS
DTPA
N48720* --Life Sciences--Nuclide Kinetics & Toxicology-- Animals
PLUTONIUM NITRATES
PLUTONIUM OXIDES