FURTHER STUDIES ON THE EOSINOPHILIC RESPONSE OF RATS INFECTED WITH IRRADIATED TRICHINELLA
Journal Article
·
· Exptl. Parasitol.
Rats were infected with Trichinella larvae subjected to sterilizing doses (12,000 and 14,000 r) of x radiation. During the course of such infections, which were limited to the intestine, circulating eosinophilia failed to develop in rats infected with larvae subjected to 12,000 r. In another experiment, similar rats infected with larvae exposed to 14,000 r did develop a marked eosinophilic response, in contrast to the previous report. It is not clear why in earlier studies Trichinella irradiated with 12,000 or 16,000 r failed to stimulate an eosinophilia, while similar larvae irradiated with 14,000 r did. One possible explanation offered is that a certain dose of x ray damages eosinophilogenic centers or substances in the parasite while other doses may stimulate such factors. It is also possible that 14,000 r might damage certain structures in such a fashion as to endow them with eosinophilogenic properties. It is concluded that irradiated larvae may or may not stimulate the host's eosinophil response even in the absence of the second generation of parasites. Thus the irradiation technique as used here does not provide an unequivocal answer to the question originally proposed, namely, can or does the intestinal phase of infection with Trichinella initiate the characteristic eosinophilia associated with trichinosis? A different approach to the problem is required. (BBB)
- Research Organization:
- Albert Einstein Medical Coll., New York
- NSA Number:
- NSA-18-017516
- OSTI ID:
- 4050567
- Journal Information:
- Exptl. Parasitol., Journal Name: Exptl. Parasitol. Vol. Vol: 14
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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