Pathogenetic mechanisms in immune polioencephalomyelitis: induction of disease in immunosuppressed mice
Immune polioencephalomyelitis (IPE) was induced by the i. p. injection of x-irradiated (10,000 R) syngeneic line I/sub b/ malignant lymphocytes into C58 mice that were 7 or more months old and in young mice immunosuppressed by x-ray or drugs. The occurrence of IPE in young immunosuppressed C58 mice was systematically analyzed. When mice less than 2 weeks old were x-irradiated with 600 R, IPE could not be induced. The incidence in 1-month-old mice was approximately 50 percent and increased progressively with the age except for a drop in incidence at 3 months. An analysis of the dose effects of x-irradiation on the occurrence of IPE in mice of different ages revealed a marked increase in the incidence in 3- and 5-month-old mice beginning at dose levels of 450 R and 300 R, respectively. Considered together, these data indicated that two sub- populations of immunocytes differing in x-ray sensitivity interacted to protect mice from IPE. It appears that under natural conditions an x-ray sensitive cell population, possibly having suppressor function, decreased with age and made mice susceptible to induction of IPE. Five-month-old mice were immunosuppressed with an LD$sub 10$ of cyclophosphamide, prednisolone, or methotrexate to determine whether mice immunosuppressed with drugs also were susceptible to the induction of IPE. (auth)
- Research Organization:
- Univ. of Michigan, Ann Arbor
- NSA Number:
- NSA-33-029749
- OSTI ID:
- 4044172
- Journal Information:
- J. Immunol., v. 116, no. 2, pp. 475-481, Other Information: Orig. Receipt Date: 30-JUN-76
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560152* -Biomedical Sciences
Applied Studies-Radiation Effects-Radiation Effects on Animals-Vertebrates
*ENCEPHALITIS- INFECTIVITY
*ENDOXAN- BIOLOGICAL EFFECTS
*IMMUNOSUPPRESSION- BIOLOGICAL RADIATION EFFECTS
*METHOTREXATE- BIOLOGICAL EFFECTS
*POLIOMYELITIS- INFECTIVITY
*PREDNISOLONE- BIOLOGICAL EFFECTS
AGE DEPENDENCE
IMMUNE REACTIONS
LYMPHOCYTES
MICE
RADIOSENSITIVITY
X RADIATION