SOME EFFECTS OF TRITIATED THYMIDINE AS A DEOXYRIBONUCLEIC ACID LABEL IN THE RAT LIVER
tely 2 mu c/gm body weight) produces changes in the ploidy classes of the liver cell nuclei of the 3-week-old rat within 24 hours. Two weeks after its administration the ploidy classes are changed further and are similar to those of the 2-year-old control. Histological evidence of cellular injury is limited to cytoplasmic vacuolization and reduction of RNA during the first 2 days after tritiated thymidine. Radiation resistance appears to develop in the liver within 2 weeks after the initial exposure period. The ploidy changes appear to represent an early stage in the spectrum of alterations after irradiation, and their study offers a useful method in the investigation of the effects of radiation on cells. In the use of radioactive labeling materials for metabolic studies, the internal radiation so introduced may alter the biological system under investigation. (auth)
- Research Organization:
- Goldwater Memorial Hospital, Welfare Island, New York
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-15-022124
- OSTI ID:
- 4042829
- Journal Information:
- Radiation Research, Journal Name: Radiation Research Vol. Vol: 14
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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