BIOLOGY AND MEDICINE SEMIANNUAL REPORT, SPRING 1961
The experimental setup snd dosimetry are described for exposing biologic samples in the wet state and under controlled gaseous atmospheres to the effects of heavy ions from a linear accelerator. The use of fluorescein staining as a sensitive and semiquantitative indicator of injury to brain tissue following localized irradiation by alpha particles from the 184-in. cyclotron is described. The method was used to demonstrate the greater radiosensitivity of the primate brain. Data are included from studies on monkeys, rats, and rabbits. Results are included from preliminary studies on the effect of a complexing agent and mode of administration on the distribution of Cm/sup 2//sup 4//sup 2/ in rats. Tracer studies in female cancer patients who had received pituitary irradiation gave evidence in support of a direct conversion of testosterone to estrogens. The apparatus and prccedures are described. High-resolution radioautography, following the administration of tritiated thymidine to mice, was used to study plasmocytopoiesis in the regional lymph nodes of mice after multiple injections of antigen. Procedures and results are described. Studies of mating behavior in Drosophila are reported in which the mating preferences of D. melanoaaster were determined when individual males were allowed to choose between two females of the same genotype or two females of different genotypes. Results are reported from a series of studies on the effects of radiation on proteins. The results support the concept that major chemical effects of both the direct and indirect action of ionizing radiation on protein involve reactions at C-N bond loci, that these reactions under appropriate conditions can lead to C-N bond cleavage, and . that the fundamental characteristics of the cleavage reactions are essentially independent of the mature of the group or linkage with which the C-N bond is associated. Studies on the chemical nature of erythropoietic hormone activity are described. Whole-body radioactivity counts are reported for normal individuals, patients with tracer doses of Fe5/sup 5//sup 9/, and a variety of cases of exposure to intermal radionuclides. A list is included of staff publications during the period covered. (C.H.)
- Research Organization:
- California. UNiv., Berkeley. Lawrence Radiation Lab.
- DOE Contract Number:
- W-7405-ENG-48
- NSA Number:
- NSA-15-023206
- OSTI ID:
- 4042198
- Report Number(s):
- UCRL-9617
- Resource Relation:
- Other Information: Orig. Receipt Date: 31-DEC-61
- Country of Publication:
- United States
- Language:
- English
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