DISTRIBUTION AND EXCRETION OF NIOBIUM-95 IN RATS FOLLOWING DAILY ADMINISTRATION IN THE FOOD AND DRINKING WATER

Technical Report · Thu Dec 15 04:00:00 EST 1960

OSTI ID:4041184

Thomas, R G; Lie, R; Djuric, D; Feola, J; Scott, J K

Tracer Nb/sup 95/ in oxalic acid solution was added to the food and drinking water of rats and fed daily for thirteen and twelve days, respectively. Serial sacrifices for limited tissue distribution studies were performed throughout and following the feeding period. All food administered, food remaining, excreta, and the whole animals were measured for their gamma activity of the isotope, to permit a balance study. Recovery throughout was approximately- 94 per cent. Ninety-nine to ninety-nine per cent of the niobium ingested. either mixed with food or drinking water, passed directly through the gastrointestinal (GI) tract. The amount entering blood brought the body burden (whole animal mimus GI tract and contents) to a steady state value after just a few days of continued ingestion. This steady state value was between two and five per cent of the average daily intake. There is no indication from these data that the currently recommended maximum permissible concentration in water (3 x 10/sup 03/ mu c/cc for a 40-hour work week) is not valid. (auth)

• Research Organization: Rochester, N.Y. Univ. Atomic Energy Project
• NSA Number: NSA-15-015348
• OSTI ID: 4041184
• Report Number(s): UR-584
• Country of Publication: United States
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
BLOOD
FOOD
GAMMA RADIATION
INTESTINE
METABOLISM
NIOBIUM 95
RATS
STOMACH
TISSUES
WATER