INHIBITION OF DNA SYNTHESIS IN MURINE BONE-MARROW CELLS BY AET AND CYSTEAMINE

Journal Article · Tue Mar 31 04:00:00 EST 1964 · Annals of the New York Academy of Sciences (U.S.)

DOI:https://doi.org/10.1111/j.1749-6632.1964.tb53616.x· OSTI ID:4038674

La Salle, M; Billen, D

Studies were designed to determine whether AET and cysteamine would alter DNA synthesis in mammalian hemic cells. in vivo studies were performed on young male Swiss mice injected with tritiated thymidine, and in vitro studies were made with bone marrow from either hybrid or Swiss mice. In the in vitro studies a one-hour exposure to tritiated thymidine was allowed. It was shown that AET administered to mice, at times and concentrations compatible with its use as a radioprotective agent both in vitro and in vivo leads to a marked inhibition of DNA synthesis. Cysteamine also inhibited bone-marrow DNA synthesis in vitro. (H.M.G.)

• Research Organization: Univ. of Texas; M.D. Anderson Hospital; and Tumor Inst., Houston
• Sponsoring Organization: USDOE
• NSA Number: NSA-18-019524
• OSTI ID: 4038674
• Journal Information: Annals of the New York Academy of Sciences (U.S.), Journal Name: Annals of the New York Academy of Sciences (U.S.) Vol. Vol: 114; ISSN ANYAA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

AET
AMINES
BIOCHEMISTRY
BIOLOGY AND MEDICINE
BLOOD CELLS
BONE MARROW
DNA
ETHYL RADICALS
HETEROCYCLICS
LABELLED COMPOUNDS
MEA
METABOLISM
MICE
NUCLEIC ACIDS
NUCLEOSIDES
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
PYRIMIDINES
RADIATION PROTECTION
THYMIDINE
THYMINE
TRACER TECHNIQUES
TRITIUM
USES