OCTANOATE OXIDATION IN THE CERIUM-INDUCED FATTY LIVER

Journal Article · Thu Dec 31 23:00:00 EST 1959 · Biochim. et Biophys. Acta

DOI:https://doi.org/10.1016/0006-3002(60)90483-2· OSTI ID:4035616

Snyder, F; Baker, F; Rafter, J; Kyker, G C

A practically complete inhibition of octanoate oxidation by liver mitochondria was observed in rats killed two days after the administration of stable cerium. A wide range of values was observed from days 1 through 6 which was similar to the variation of liver lipids during the onset and recovery phases of fatty infiltration in rats exposed to cerium. Data ars presented graphically from which it was concluded that the development of the fatty liver and the recovery of the liver from lipid infiltration depend on the ability of mitochondrial fatty acid oxidizing systems to function properly. Lipid mobilization from extrahepatic tissues appeared to be a significant source of the abnormal accumulation of liver lipids after a single cerium injection. (C.H.)

• Research Organization: Oak Ridge Inst. of Nuclear Studies, Tenn.
• NSA Number: NSA-15-015359
• OSTI ID: 4035616
• Journal Information: Biochim. et Biophys. Acta, Journal Name: Biochim. et Biophys. Acta Vol. Vol: 43
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
CERIUM
LIPIDS
LIVER
MITOCHONDRIA
OCTANOIC ACID
ORGANIC ACIDS
OXIDATION
RATS
RECOVERY
SALTS
TISSUES