The Protective Effect of Cysteamine ($beta$-Mercaptoethylamine) on Chromosome Rearrangements in the Tissues of Monkeys and Mice; ZASHCHITNYI EFFEKT TSISTEAMINA ($beta$-MERKAPTOETILAMINA) NA KHROMOSOMNYE PERESTROIKI V TKANYAKH OBEZ'YAN I MYSHEI
Technical Report
·
· Akademiya Nauk S.S.S.R.
OSTI ID:4035137
Data are presented on the protective effects of cysteamine against radioinduced chromosome disturbances in gonad germ cells and in bone marrow cells. The data were taken from studies on Macaca mulatta monkeys. Intraperitoneal injections of 3 mg cysteamine, considered to be 150 mg/kg for mice and 100 mg/kg for monkeys, indicated mean protective effects on cells of genetic material epithelium and on bone marrow as 42.75 and 50.77% for mice and 52.4 and 50.8% for monkeys. Cytological studies confirm the higher radiosensitivity of genetic material epithelium cells in monkeys as compared to mice. It is postulated that cysteamine chromosome protection is due to a complex formation of cysteamine molecules with desoxyribonucleic acids. (R.V.J.)
- Research Organization:
- Originating Research Org. not identified
- NSA Number:
- NSA-15-015460
- OSTI ID:
- 4035137
- Report Number(s):
- A/AC.82/G/L.410
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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