THE EFFECTIVENESS OF WATER-ELECTROLYTE REPLACEMENT THERAPY AND OF ANTIBIOTIC TREATMENT AGAINST ACUTE (3-5 DAY) INTESTINAL RADIATION DEATHS IN THE RAT
The administration of sterile 0.9% solution containing either NaCl or a mixture of NaCl, Na lactate, and KCl during the critical 2 to 5 days following irradiation had little protective effect. However, treatment with antibiotics during the same period definitely increased the number of survivors. Results suggest that both dehydration and bacteremia are causalIy related in the genesis of acute intestinal radiation deaths in the rat. A comparison between whole-body and abdomen-only irradiated animals given 910r showed that the therapeutic measures used were about equally effective against acute intestinal radiation death in both cases. The therapeutic measures were ineffective against deaths occurring primarily as a result of radiation induced injury to the hematopoietic system. (P. C.H.)
- Research Organization:
- Naval Radiological Defense Lab., San Francisco
- NSA Number:
- NSA-15-023352
- OSTI ID:
- 4034552
- Report Number(s):
- USNRDL-TR-516
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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