STUDIES ON ANTIBODY FORMATION. EFFECTS OF X-IRRADIATION ON ADAPTATION FOR THE SECONDARY RESPONSE OF RABBITS TO BOVINE $gamma$-GLOBULIN

Journal Article · Sun May 01 04:00:00 EDT 1960 · Journal of Immunology (U.S.)

OSTI ID:4026168

Porter, R J

The effects of whole-body x irradiation of rabbits on the adaptation for a secondary antibody response were studied under various conditions. X ray in a dose of 550 r 24 hr before a first injection of bovine gamma -giobulin prevented both adaptation and antibody formation, as measured by hemagglutination of tannic acid-coated erythrocytes. X ray during the latent period between the first and second injections destroyed or markedly depressed adaptation. However, when x irradiation in this period was followed 24 hr later by an injection of antigen, adaptation for a later secondary response was either preserved or reestablished. These results are interpreted to mean that during a secondary response at least part of the adaptation for subsequent secondary responses arises from the interaction of antigen with an adapted system. This suggests that the individual cells which produce antibody may later become adapted for a secondary response. (auth)

• Research Organization: Univ. of Michigan, Ann Arbor
• NSA Number: NSA-15-016842
• OSTI ID: 4026168
• Journal Information: Journal of Immunology (U.S.), Journal Name: Journal of Immunology (U.S.) Vol. Vol: 84; ISSN JOIMA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ANIMAL CELLS
ANTIBODIES
ANTIGENS
BIOLOGY AND MEDICINE
BODY
ERYTHROCYTES
GLOBULINS
IMMUNITY
IRRADIATION
PROTEINS
RABBITS
RADIATION DOSES
RADIATION EFFECTS
WHOLE-BODY IRRADIATION
X RADIATION