STUDIES IN THE METABOLISM OF CARRIER-FREE RADIORUTHENIUM. I. PRELIMINARY INVESTIGATIONS

Journal Article · Sat Apr 01 04:00:00 EST 1961 · J. Nuclear Energy, Pts. A & B. Reactor Sci. and Technol.

DOI:https://doi.org/10.1016/0368-3230(61)90068-4· OSTI ID:4024529

Bruce, R S; Carr, T E.F.

Carrier-free radioruthenium (Ru/sup 106/) in different chemical forms is administered orally to rabbits and rats and the uptake and distribution in the body are determined. Derivatives of nitrosyl-ruthenium are absorbed to the greatest extent, uptake averaging 13 per cent by rabbits and 8 per cent by rats. The uptske of ruthenium chloride is lower and does not differ significantly from that of the dioxide in the absence of carrier. Uptake of all forms is rapid but a high proportion of the dose absorbed is excreted in the urine within 3 days. While the chemical nature of ruthenium considerably affects absorption, it does not influence the subsequent distribution. For the first few days after ingestion of ruthenium, the gastrointestinal tract and the kidneys are subjected to the highest concentrations of ruthenium. (auth)

• Research Organization: Medical Research Council Radiobiological Research Unit, Harwell, Berks, Eng.
• NSA Number: NSA-15-024664
• OSTI ID: 4024529
• Journal Information: J. Nuclear Energy, Pts. A & B. Reactor Sci. and Technol., Journal Name: J. Nuclear Energy, Pts. A & B. Reactor Sci. and Technol. Vol. Vol: 4
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ABSORPTION
BIOLOGY AND MEDICINE
INTESTINE
KIDNEYS
METABOLISM
QUANTITY RATIO
RABBITS
RATS
RUTHENIUM 106
RUTHENIUM CHLORIDES
RUTHENIUM OXIDES
STOMACH
URINE