New Stopping Criteria for Segmenting DNA Sequences

Journal Article · Mon Jun 18 00:00:00 EDT 2001 · Physical Review Letters

DOI:https://doi.org/10.1103/PhysRevLett.86.5815· OSTI ID:40204697

Li, Wentian

We propose a solution on the stopping criterion in segmenting inhomogeneous DNA sequences with complex statistical patterns. This new stopping criterion is based on Bayesian information criterion in the model selection framework. When this criterion is applied to telomere of S.cerevisiae and the complete sequence of E.coli, borders of biologically meaningful units were identified, and a more reasonable number of domains was obtained. We also introduce a measure called segmentation strength which can be used to control the delineation of large domains. The relationship between the average domain size and the threshold of segmentation strength is determined for several genome sequences.

• Sponsoring Organization: (US)
• OSTI ID: 40204697
• Journal Information: Physical Review Letters, Vol. 86, Issue 25; Other Information: DOI: 10.1103/PhysRevLett.86.5815; Othernumber: PRLTAO000086000025005815000001; 012125PRL; PBD: 18 Jun 2001; ISSN 0031-9007
• Publisher: The American Physical Society
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
DNA
TELOMERES
INFORMATION THEORY
MICROORGANISMS
GENETICS