STUDIES ON THE COMPOUND LIPIDS FROM X-RAY IRRADIATED ANIMALS. II. BIOLOGICAL AND BIOCHEMICAL PROPERTIES OF THE COMPOUND LIPIDS IN THE X-RAY IRRADIATED RABBIT ORGANS
ABS>To clarify the mechanlsm of the indirect tissue damage by radioinduced lipid changes, lipids of rabbits irradiated with 3000 r were fractionated by silicic acid chromatography and tested for biologic activity on cultures of L cells. Postirradiation incorporation of /sup 32/P-labeled lipids in tissues was also studied. The lipid (lysophosphatide-rich fraction) isolated from irradiated rabbit organs possessed a strong hemolytic action and an ability to inhibit L cell proliferation as well as to accelerate the respiration of mitochondria in the rabbit liver and spleen. It was also shown that they act as to induce a marked swelling of mitochondria, impeding the formation of high- energy phosphate and acting as an uncoupler of oxidative phosphorylation in vivo. The uptake of /sup 32/P-labeled lipids was marked in spleen, bone marrow, and liver of both irradiated and nonirradiate'd groups. The uptake of /sup 32/P- labeled lipids in rabbits given intravenous injections of lipid fractions for 30 consecutive days previously was found to be greatest in pancreas followed by bone marrow, spleen, liver in the male group, whereas it is greatest in spleen, followed by liver and bone marrow in females. It is proposed to lipids liberated and altered by irradiation may act on the bone marrow to depress hematopoiesis. (BBB)
- Research Organization:
- Okayama Univ., Japan
- NSA Number:
- NSA-18-019561
- OSTI ID:
- 4019895
- Journal Information:
- Acta Medica Okayama (Japan), Journal Name: Acta Medica Okayama (Japan) Vol. Vol: 17; ISSN AMOKA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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Related Subjects
ANIMALS
BIOCHEMISTRY
BIOLOGY
BIOLOGY AND MEDICINE
BLOOD FORMATION
BONE MARROW
CHROMATOGRAPHY
CYTOLOGY
GLANDS
IRRADIATION
LABELLED COMPOUNDS
LIPIDS
LIVER
METABOLISM
MITOCHONDRIA
OXIDATION
PANCREAS
PHOSPHORUS 32
QUALITATIVE ANALYSIS
RABBITS
RADIATION DOSES
RADIATION EFFECTS
RADIATION INJURIES
SEPARATION PROCESSES
SEX
SPLEEN
STANDARDS
TISSUES
TOXICITY
VARIATIONS
X RADIATION