MYELOID LEUKEMIA IN THE MOUSE

Journal Article · Tue Mar 31 04:00:00 EST 1964 · Annals of the New York Academy of Sciences (U.S.)

DOI:https://doi.org/10.1111/j.1749-6632.1964.tb53574.x· OSTI ID:4019435

Upton, A C; Jenkins, V K; Conklin, J W

The incidence of myeloid leukemia is elevated in RF mice acutely exposed early in adult life to 50 to 400 rads of whole-body x radiation. The relation between incidence and dose is complex, the yield of leukemias declining as the dose is increased above an optimal level. X rays and gamma rays are less leukemogenic when administered daily at low dose rates than when administered in one or two large exposures at high dose rates. The leukemogenic effectiveness of fast neutrons depends on the neutron energy but appears generally comparable to that of x rays. In contrast, however, the effectiveness of fast neutrons shows no detectable reduction with decrease in dose rate. A given dose in air to part of the body is less leukemogenic than the same dose in air to the whole body, but quantitative data on the relative importance of the integral dose and of the volume and region of the body irradiated are not available. The average induction period of leukemia after wholebody x irradiation is 6 to 12 months depending on the dose, although the earliest radiogenic leukemias become detectable within two months. In contrast to the relatively long average latency of leukemia induced by irradiation, the neoplasm appears in a significant number of nonirradiated recipients within one month after injection of cellfree filtrates of leukemic tissue. The age-specific death rate from the disease is biphasic. Radiation markedly advances the onset of the early peak, which occurs in controls between the fifteenth and eighteenth months of life. Radiation affects the late peak (occurring at 22 to 24 months) relatively less, if at all. The results of these studies suggest that the leukemic transformation induced by radiation evolves through multiple changes rather than through a single, one-hit type of alteration in a host cell or in the virus-host relation. (auth)

• Research Organization: Oak Ridge National Lab., Tenn.
• Sponsoring Organization: USDOE
• NSA Number: NSA-18-019577
• OSTI ID: 4019435
• Journal Information: Annals of the New York Academy of Sciences (U.S.), Journal Name: Annals of the New York Academy of Sciences (U.S.) Vol. Vol: 114; ISSN ANYAA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ANIMAL CELLS
BIOLOGY AND MEDICINE
BODY
CARCINOGENESIS
DISEASES
FAST NEUTRONS
GAMMA RADIATION
IRRADIATION
LETHAL DOSE
LEUKEMIA
MICE
RADIATION DOSES
RADIATION EFFECTS
RADIATION SICKNESS
SOLUTIONS
STANDARDS
TARGETS
TISSUES
TRANSPLANTS
VIRUSES
X RADIATION