EFFECT OF ABDOMINAL SHIELDING ON THE METABOLISM OF HYDROCORTISONE BY LIVER TISSUE OF X-IRRADIATED RATS
Liver slices removed from adult rats at various times following whole body x-irradiations of 850, 1500, and 2000 r were tested for their ability to metabolize hydrocortisone ( free alcohol). The animals were divided into a non- irradiated control group, an irradiated unshielded group, and an abdominal- shielded irradiated group. It was found that the irradiated unshielded liver slices metabo lized the hydrocortisone at a lower rate than control slices. Liver slices removed from animals whose abdominal regions were shielded during irradiation were found to metabolize hydrocortisone at a higher rate than control slices. The effects observed appeared to be dependent on total dosage and time of removal of the liver post-irradiation. (auth)
- Research Organization:
- North Texas State Coll., Denton
- NSA Number:
- NSA-15-017961
- OSTI ID:
- 4013150
- Journal Information:
- Texas J. Sci., Vol. Vol: 13; Other Information: Orig. Receipt Date: 31-DEC-61
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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