EXPERIMENTAL STUDIES ON THE NATURE OF X-RAY INJURIES. I. INFLUENCES OF CYTOTOXIN, PRODUCED BY LARGE-DOSE RADIATION, ON VARIOUS TISSUES (BLOOD CELLS AND TESTES IN PARTICULAR)
The nature of cytotoxin produced by x irradiation and particularly its influence on various tissues, such as blood cells and testes, was studied. The unsaturated fatty acid fraction, extracted from the liver of a rabbit, irradiatsd with 3000 r was injectsd intravenously into another group of normal rabbits. The leucocyte count of the serabbits decreased to about the same amount as in the rabbits exposed directly to x rays. Toxic granules in the leucocytes were observed in both cases. The histological changes in the testes were the same as in those irradiated directly on the testes, such as the disappearance of spermatozoa, an inhibitory picture of the mitosis of the spermatogonia, and appearance of polykaryocytes. From these findings it may be concluded that when x rays were given, biochemical changes occurred in living tissue cells to produce an unsaturated fatty acid fraction which injured the normal cells. (Abstr. Japan Med., 1: No. 9, 1961)
- Research Organization:
- Okayama Univ., Japan
- NSA Number:
- NSA-15-025924
- OSTI ID:
- 4009976
- Journal Information:
- Nippon Igaku Hoshasen Gakkai Zasshi (Japan), Journal Name: Nippon Igaku Hoshasen Gakkai Zasshi (Japan) Vol. Vol: 19; ISSN NHGZA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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