Reactions of thiols with individual DNA base radicals in DNA and DNA model systems: The effect of oxygen on radioprotection
Conference
·
OSTI ID:400721
- Oakland Univ., Rochester, MI (United States). Dept. of Chemistry
Thiol radioprotection of DNA in the living cell has been suggested to be a result of hydrogen or electron donation to free radicals generated on DNA resulting in a repair of the original radical lesion. Thus far there are no reports of reactions of DNA anion radicals with thiols. Oxygen involvement in thiol free radical reactions has been implicated in oxygen radiosensitization of cells to the lethal effects of radiation. A biological oxygen enhancement effect and a chemical oxygen enhancement effect have both been recognized. One hypothesis is that thiyl radical reactions with oxygen are the source of the chemical oxygen enhancement effect.
- DOE Contract Number:
- FG02-86ER60455
- OSTI ID:
- 400721
- Report Number(s):
- CONF-9410280--; ISBN 0-935470-90-5
- Country of Publication:
- United States
- Language:
- English
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