Part 1: (Previous year`s abstract) toxic equivalency factors (TEFs) of polychlorinated and polybrominated biphenyls, dibenzo-p-dioxins, dibenzofurans and polychlorinated diphenylethers based on early life stage mortality of rainbow trout

Conference · Sat Dec 31 04:00:00 EST 1994

OSTI ID:40042

Hornung, M W; Zabel, W E; Abnet, C C; Peterson, R E ^[1]; Chu, I ^[2]; Safe, S H ^[3]; Cook, P M ^[4]

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1. Univ. of Wisconsin, Madison, WI (United States)
2. Health and Welfare Canada, Ottawa, Ontario (Canada)
3. Texas A and M Univ., College Station, TX (United States)
4. Environmental Protection Agency, Duluth, MN (United States)

Polychlorinated and polybrominated biphenyls (PCBs, PBBs), dibenzo-p-dioxins (PCDDs, PBDDs) and furans (PCDFs, PBDFs), along with mixed polychlorinated/brominated dibenzo-p-dioxins (PC/BDDs) and polychlorinated diphenylethers (PCDPEs), comprise a complex mixture of chemicals found in aquatic environments which may pose a risk to fish early life stage survival. To evaluate this potential risk, the lethal potency of individual congeners relative to TCDD must be determined. TEFs were calculated based on the ratio of TCDD LD{sub 50} to congener LD{sub 50} in rainbow trout. Mortality was assessed from hatching to swim-up; no congener related mortality occurred during the egg stage. TEFs from PCBs and PBBs were; 3,4,4{prime},5-TCB (IUPAC {number_sign}81) = 0.0056; 3,3{prime},4,4{prime}-TBB ({number_sign}77) = 0.002; 3,3{prime},4,4{prime},5,5{prime}-HxBB ({number_sign}169) = 0.0001. PCBs {number_sign}4, {number_sign}28, {number_sign}52, {number_sign}105, {number_sign}118, {number_sign}128, {number_sign}138, {number_sign}156, {number_sign}170 and PBBs {number_sign}4, {number_sign}52, {number_sign}153 all had TEF values < 0.00005. TEFs for PCDDs and PBDDs were: 1,2,3,6,7,8-HxCDD = 0.024; 1,2,3,4, 6,7,8-HpCDD = 0.0020; 2,3,7,8-TBDD = 1.5; 1,2,3,7,8-PeBDD = 0.08. Of two PBDFs tested, 1,2,3,7,8-PeBDF had TEF = 0.04 and 2,7-DBDF, had TEF < 0.0004. TEFs for two equipotent PC/BDDs, 2,3,7,-Cl-8-BrDD and 2,8-Cl-3,7-BrDD were 0.6. PCDPEs 3,3{prime}4,4{prime}-; 2,3{prime},4{prime}, 6-; 2,2{prime},4,5,6{prime}-; 2,3{prime},4,4{prime},5-; and 3,3{prime},4,4{prime},5 had TEFs < 0.000002.

• OSTI ID: 40042
• Report Number(s): CONF-9410273--
• Country of Publication: United States
• Language: English

Related Subjects

56 BIOLOGY AND MEDICINE
APPLIED STUDIES
AGE DEPENDENCE
DIOXIN
FURANS
POLYCHLORINATED BIPHENYLS
SENSITIVITY
TOXICITY
TROUT
WATER POLLUTION