THE SIGNIFICANCE OF OVARIAL HORMONES IN THE PATHOGENESIS OF RADIATION DAMAGE IN RAT EMBRYOS AFTER THE IRRADIATION OF FEMALE GAMETES WITH X-RAYS (in Russian)
Journal Article
·
· Doklady Akad. Nauk S.S.S.R.
OSTI ID:4003240
White female rats were given a whole-body, x-ray dose of 600 r under the following conditions: 1) irradiation before pregnancy; 2) irradiation and transplantation of two healthy ovaries directly after irradiation; 3) irradiation and transplantation of two healthy ovaries on the day of conception; 4) irradiation and transplantation of two healthy ovaries directly after irradiation with subsequent removal of the transplant on the day of conception. The period between the time of irradiation and the time of conception varied from 1 to 10 days. The percent of implantations and of dead embryos was determined on the 17th day of pregnancy. The results show that the percent of live embryos is 10.2 plus or minus 5.1% greater for the irradiated rats with transplantation than for the irradiated rats without transplantation. If the transplantation is made on the day of conception, no effect is observed on the implantation and survival of the embryos as compared to the results obtained with transplantation. However, if the transplantation is carried out at some period of time before pregnancy and then the transplant is removed on the day of conception, the number of live embryos increased by 10.3% (with an error of plus or minus 4.7%). Thus, the transplantation of healthy ovaries to irradiated rats increases the post- implantation survival of the embryos only if the transplantation is made before pregnancy, and the effect can be observed even if the transplant is removed in the very earliest stages of embryonic development. It is assumed that hormones from the ovaries have a beneficial effect on tae survival of the embryos in the post-implantation period. (TTT)
- Research Organization:
- Inst. of Experimental Medicine, Academy of Sciences, USSR
- NSA Number:
- NSA-15-019167
- OSTI ID:
- 4003240
- Journal Information:
- Doklady Akad. Nauk S.S.S.R., Journal Name: Doklady Akad. Nauk S.S.S.R. Vol. Vol: 137
- Country of Publication:
- Country unknown/Code not available
- Language:
- Russian
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