NUMBER OF RAT OVA IMPLANTING AFTER SUB-STERILIZING X-IRRADIATION OF ONE OR BOTH OVARIES
Both bilateral and unilateral irradiation of the ovary with a substerilizing dose (800 r) was undertaken in an attempt to clarify the direct effects on fertility of ovarian irradiation. In some cases, one ovary had been removed from the 60-day-old rats before irradiation of the other ovary. Treated females were placed with males at 60, 70, 80, or 90 days of age, and examined, 8 or 9 days after sperm were found in the vaginal smears, to determine the number of implantations. The number of matings was reduced during the period of normal vagtnal cycles. Matings did occur after the onset of continuous vaginal cornification. Animals with an irradiated left and a normal right ovary maintained an average number of implantations through pregnancies 1 to 7. The normal ovary compensated for the loss of production by the irradiated ovary. Bilateral irradiation caused a decrease in implantations in the second and third pregnancies. In individual cases, however, the normal complement for a single ovary occurred as late as 201 days after irradiation. The irradiated ovary in the absence of the other ovary compensated by producing more implantations; its period of production was limited to 31 days following irradiation. The average number of implantations was 8.4, which is significantly greater than the number of implantations produced by the irradiated ovary in the presence of a normal or an irradiated ovary during a comparable postirradiation period. Thus the irradiated ovary during this period can compensate by producing more ova if the other ovary has been removed. There was no evident explanation for the failure of these animals to implant at a later date. Resorptions were noted at the time of exploration, but no attempt was made to determine the time or the cause of these. (BBB)
- Research Organization:
- Univ. of Illinois, Chicago
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-18-011661
- OSTI ID:
- 4107362
- Journal Information:
- Anat. Record, Journal Name: Anat. Record Vol. Vol: 146
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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