THE MECHANISM OF THE PROTECTIVE ACTION BY SHIELDING THE ORGANS DURING THE TOTAL IRRADIATION OF RATS (in Russian)
The effectiveness of shielding portions of the body during total body irradiation has been established previously when it was noticed the survival rate increases considerably upon shielding the spleen, kidney, intestines, or the appendix of the test animals. In order to study the mechanism involved, the spleen of male mice exposed to 500 r total body x-ray dose was protected by removing it from the bedy and placing it in a Pb shield; in a similar series the shield was omitted. In another series the rear feet and the tail of the animals were shielded. In both cases the rate of survival was increased threefold. Making cytolysin determinations on the various animals it was found that whenever the spleen or the bone marrow (limbs or tail) were protected during the irradiation, the leucolysin production was reduced, probably because the shielding reduces the number of cells directly injured by the radiation resulting in a reduced rate of formation of the decomposition products which exert an autoimmunizing action. (TTT)
- Research Organization:
- Originating Research Org. not identified
- NSA Number:
- NSA-15-019196
- OSTI ID:
- 4002974
- Journal Information:
- Meditsinskaya Radiologiya (U.S.S.R.) For English translation see Med. Radiol., USSR, Vol. Vol: 6: No. 2; Other Information: Orig. Receipt Date: 31-DEC-61
- Country of Publication:
- Country unknown/Code not available
- Language:
- Russian
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