The effects of smoltification on the uptake, distribution and metabolism of benzo[a]pyrene in coho salmon
Conference
·
OSTI ID:398228
- Simon Fraser Univ., Burnaby, British Columbia (Canada)
Benzo[a]pyrene uptake, distribution and metabolism patterns were investigated from February to June during the transformation of freshwater coho salmon (Oncorhynchus kisutch) liparr to smolts. At a constant benzo[a]pyrene concentration of 5ug/L, BaP uptake rates increased from 0.01 ug-h{sup {minus}1}-g{sup {minus}1} in February to 0.04 ug-h{sup {minus}1}-g{sup {minus}1} in May and declined to 0.03 ug-h{sup {minus}1}-g{sup {minus}1} in June. Following a 24 hour exposure, the accumulation of BaP in the liver, gills, visceral fat and kidney increased from February to May and declined to June. This pattern appeared to be due to changes in BaP uptake rates. In contrast, the percent body burden in bile remained low (20--25%) until the end of May when it increased to 45-50%. The amounts of BaP in the tissues such as stomach, intestine, skin, muscle, and brain did not show significant differences throughout the study. An analysis of bile suggested that coho salmon parr and smolts are capable of metabolizing benzo[a]pyrene via Phase 1 and Phase 2 transformation reactions to glucuronide, sulfate and possibly glutathione conjugates. The majority of BaP metabolites in the bile were unidentified water-soluble compounds.
- OSTI ID:
- 398228
- Report Number(s):
- CONF-9511137--; ISBN 1-880611-03-1
- Country of Publication:
- United States
- Language:
- English
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Tue Jul 01 00:00:00 EDT 1997
· Environmental Toxicology and Chemistry
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OSTI ID:514568
The effects of smoltification on the distribution, metabolism and elimination of benzo[a]pyrene in juvenile coho salmon, Oncorhynchus kisutch
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Sat Dec 30 23:00:00 EST 1995
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OSTI ID:398229
Hormonal regulation of lipid metabolism in developing coho salmon, Oncorhynchus kisutch
Thesis/Dissertation
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Mon Dec 31 23:00:00 EST 1984
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OSTI ID:6792085