Effect of feeding rate on biochemical measures and fate of a single oral dose of PCB in Arctic char
Conference
·
OSTI ID:392311
- Univ. of Manitoba, Winnipeg, Manitoba (Canada). Dept. of Zoology
- Dept. of Fisheries and Oceans, Winnipeg, Manitoba (Canada)
This study was done to determine the effects of reducing lipid stores and the resulting mobilization of associated contaminants. Individually tagged Arctic char (Saivelinus alpinus) were treated with single gavage doses of 6.1 ng/g {sup 14}C-3,3{prime}4,4{prime},5-pentachlorobiphenyl (PCB 126) in gelatin or vehicle (controls). Following treatment, the PCB was allowed 3 weeks to reach equilibrium distribution within the fish. After this 3 week period, treated and control groups of fish were fed one of three rations, (1.5%, 0.75% or 0.25% body wt/d). Fish were sampled at 0, 8, 24 and 48 weeks following the initiation of the different rations. PCB concentrations and lipid levels were measured in 5 tissues (muscle, liver, intestine, spleen and kidney). Biochemical response measured included hepatic EROD, retinoids and tocopherol. Growth was reduced in both treated and control groups fed the lowest ration. EROD activity was negatively correlated with growth and positively correlated with liver concentrations of PCB 126. Declines in mean lipid content were ration dependent. Changes in hepatic retinoids were related to both ration and treatment. The results indicate that a low ration resulted in greater utilization of stored lipids and higher tissue concentrations of contaminants compared to the other rations. These changes altered biochemical measures which are responsive to planar chlorinated aromatic hydrocarbons.
- OSTI ID:
- 392311
- Report Number(s):
- CONF-9511137--; ISBN 1-880611-03-1
- Country of Publication:
- United States
- Language:
- English
Similar Records
HPLC determination of tocopherol, retinol, dehydroretinol and retinyl palmitate in tissues of Lake Char (Salvelinus namaycush) exposed to coplanar 3,3[prime],4,4[prime],5-pentachlorobiphenyl
Thyroid hormone kinetics in lake trout (Salvelinus namaycush) exposed to PCB 126
Mixed-function oxidase enzyme activity and oxidative stress in lake trout (Salvelinus namaycush) exposed to 3,3{prime},4,4{prime}5-pentachlorobiphenyl (PCB-126)
Journal Article
·
Mon Feb 28 23:00:00 EST 1994
· Environmental Toxicology and Chemistry; (United States)
·
OSTI ID:5024402
Thyroid hormone kinetics in lake trout (Salvelinus namaycush) exposed to PCB 126
Conference
·
Sat Dec 30 23:00:00 EST 1995
·
OSTI ID:211969
Mixed-function oxidase enzyme activity and oxidative stress in lake trout (Salvelinus namaycush) exposed to 3,3{prime},4,4{prime}5-pentachlorobiphenyl (PCB-126)
Journal Article
·
Sat Jun 01 00:00:00 EDT 1996
· Environmental Toxicology and Chemistry
·
OSTI ID:264304