Influence of cell position relative to planar alpha-particle sources on survival and preneoplastic transformation of primary rat tracheal epithelial cells
- Oak Ridge National Laboratory, TN (United States)
- Medical Research Council, Oxon (United Kingdom)
Rat tracheal epithelial cells exposed directly on planar {sup 210}Po sources exhibited exponential cell killing; however, no significant increase in induction of preneoplastic transformation was observed over a range of {alpha}-particle fluences (0.017-0.050 {mu}m{sup {minus}2}). In contrast, up to 10-fold increases in frequencies of preneoplastic transformants, above control levels, were observed after exposure of rat tracheal epithelial cells to similar {alpha}-particle fluences on {sup 238}Pu and {sup 241}Am sources. Two alternative hypotheses are evaluated as an explanation for this apparent difference in the biological effect of {alpha} particles emitted from different sources: (a) possible interactions between effects produced by {alpha} particles and by low-energy photons, which occur with {sup 238}Pu and {sup 241}Am but not with {sup 210}Po; and (b) the influence of spatial relationships between exposed cells and the surface of the planar source. The data suggest that the cell-to-source spatial relationships affect both survival and transformation markedly. 29 refs., 4 figs., 6 tabs.
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 387380
- Journal Information:
- Radiation Research, Journal Name: Radiation Research Journal Issue: 4 Vol. 145; ISSN 0033-7587; ISSN RAREAE
- Country of Publication:
- United States
- Language:
- English
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