Do products of the myc proto-oncogene play a role in transcriptional regulation of the prothymosin {alpha} gene?
Journal Article
·
· Molecular and Cellular Biology
- National Cancer Institute, Bethesda, MD (United States); and others
This report investigates whether the Myc protein activates transcription of the human prothymosin {alpha} gene as it does in rat. The results indicate that Myc does not activate transcription; rather, it appears that the prothymosin {alpha} promoter and downstream elements are buffered so as to respond poorly to transient fluctuations in transcription factors which regulate other genes. 59 refs., 8 figs., 1 tab.
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 379268
- Journal Information:
- Molecular and Cellular Biology, Journal Name: Molecular and Cellular Biology Journal Issue: 12 Vol. 15; ISSN 0270-7306; ISSN MCEBD4
- Country of Publication:
- United States
- Language:
- English
Similar Records
Multiple mechanisms for transcriptional regulation of the myc gene family in small-cell lung cancer
NM23-H2 may play an indirect role in transcriptional activation of c-myc gene expression but does not cleave the nuclease hypersensitive element III[subscript 1]
Posttranscriptional regulation of cellular gene expression by the c-myc oncogene
Journal Article
·
Mon Aug 01 00:00:00 EDT 1988
· Mol. Cell. Biol.; (United States)
·
OSTI ID:6691950
NM23-H2 may play an indirect role in transcriptional activation of c-myc gene expression but does not cleave the nuclease hypersensitive element III[subscript 1]
Journal Article
·
Wed May 13 00:00:00 EDT 2009
· Mol. Cancer Ther.
·
OSTI ID:1018555
Posttranscriptional regulation of cellular gene expression by the c-myc oncogene
Journal Article
·
Sat Dec 31 23:00:00 EST 1988
· Molecular and Cellular Biology; (USA)
·
OSTI ID:5407181