Posttranscriptional regulation of cellular gene expression by the c-myc oncogene
Journal Article
·
· Molecular and Cellular Biology; (USA)
- Princeton Univ., NJ (USA). Dept. of Biology
The c-myc oncogene has been implicated in the development of many different cancers, yet the mechanism by which the c-myc protein alters cellular growth control has proven elusive. The authors used a cDNA hybridization difference assay to isolate two genes, mr1 and mr2, that were constitutively expressed (i.e., deregulated) in rodent fibroblast cell lines immortalized by transfection of a viral promoter-linked c-myc gene. Both cDNAs were serum inducible in quiescent G/sub o/ fibroblasts, suggesting that they are functionally related to cellular proliferative processes. Although there were significant differences in cytoplasmic mRNA levels between myc-immortalized and control cells, the rates of transcription and mRNA turnover of both genes were similar, suggesting that c-myc regulates mr1 and mr2 expression by some nuclear posttranscriptional mechanism. Their results provide evidence that c-myc can rapidly modulate cellular gene expression and suggest that c-myc may function in gene regulation at the level of RNA export, splicing, or nuclear RNA turnover.
- OSTI ID:
- 5407181
- Journal Information:
- Molecular and Cellular Biology; (USA), Journal Name: Molecular and Cellular Biology; (USA) Vol. 9:1; ISSN MCEBD; ISSN 0270-7306
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550200* -- Biochemistry
550400 -- Genetics
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANIMALS
BIOCHEMISTRY
BODY
CARCINOMAS
CELL CULTURES
CELL DIFFERENTIATION
CELL DIVISION
CHEMISTRY
CLONING
CONNECTIVE TISSUE CELLS
DISEASES
DNA HYBRIDIZATION
DNA-CLONING
FIBROBLASTS
GENE AMPLIFICATION
GENE REGULATION
GENES
GENETIC ENGINEERING
GLANDS
HYBRIDIZATION
MAMMALS
MAMMARY GLANDS
MESSENGER-RNA
MICROORGANISMS
MOLECULAR BIOLOGY
NEOPLASMS
NUCLEIC ACIDS
ONCOGENES
ONCOGENIC VIRUSES
ORGANIC COMPOUNDS
ORGANS
PARASITES
PHENOTYPE
POST-TRANSLATION MODIFICATION
RATS
RNA
RODENTS
SOMATIC CELLS
TRANSCRIPTION
VERTEBRATES
VIRUSES
550400 -- Genetics
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANIMALS
BIOCHEMISTRY
BODY
CARCINOMAS
CELL CULTURES
CELL DIFFERENTIATION
CELL DIVISION
CHEMISTRY
CLONING
CONNECTIVE TISSUE CELLS
DISEASES
DNA HYBRIDIZATION
DNA-CLONING
FIBROBLASTS
GENE AMPLIFICATION
GENE REGULATION
GENES
GENETIC ENGINEERING
GLANDS
HYBRIDIZATION
MAMMALS
MAMMARY GLANDS
MESSENGER-RNA
MICROORGANISMS
MOLECULAR BIOLOGY
NEOPLASMS
NUCLEIC ACIDS
ONCOGENES
ONCOGENIC VIRUSES
ORGANIC COMPOUNDS
ORGANS
PARASITES
PHENOTYPE
POST-TRANSLATION MODIFICATION
RATS
RNA
RODENTS
SOMATIC CELLS
TRANSCRIPTION
VERTEBRATES
VIRUSES