Wild-type human p53 transactivates the human proliferating cell nuclear antigen promoter
Journal Article
·
· Molecular and Cellular Biology
- Univ. of Texas Health Science Center, San Antonio, TX (United States)
The p53 tumor suppressor protein negatively regulates cell growth and somatic mutations in the p53 gene lead to uncontrolled cell growth and oncogenesis. This report describes research which demonstrates, using a number of different cell lines, that at low levels, wild-type p53 transactivates the human proliferating cell nuclear antigen (PCNA) promoter. When expressed at similar levels, tumor-derived p53 mutants did not transactivate the PCNA promoter. It also reports the identification of a wild-type human p53-binding site on the human PCNA promote. 84 refs., 5 figs, 3 tabs.
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 379263
- Journal Information:
- Molecular and Cellular Biology, Journal Name: Molecular and Cellular Biology Journal Issue: 12 Vol. 15; ISSN 0270-7306; ISSN MCEBD4
- Country of Publication:
- United States
- Language:
- English
Similar Records
Binding sequence-dependent regulation of the human proliferating cell nuclear antigen promoter by p53
Phosphorylation at Ser-15 and Ser-392 in mutant p53 molecules from tumors is altered compared to wild-type p53
Repression of the interleukin 6 gene promoter by p53 and the retinoblastoma susceptibility gene product
Journal Article
·
Fri Apr 15 00:00:00 EDT 2005
· Experimental Cell Research
·
OSTI ID:20717575
Phosphorylation at Ser-15 and Ser-392 in mutant p53 molecules from tumors is altered compared to wild-type p53
Journal Article
·
Thu Jul 01 00:00:00 EDT 1993
· Proceedings of the National Academy of Sciences of the United States of America; (United States)
·
OSTI ID:6281962
Repression of the interleukin 6 gene promoter by p53 and the retinoblastoma susceptibility gene product
Journal Article
·
Sun Sep 01 00:00:00 EDT 1991
· Proceedings of the National Academy of Sciences of the United States of America; (United States)
·
OSTI ID:5604146