Variant max protein, derived by alternative splicing, associates with c-Myc in vivo and inhibits transactivation

Journal Article · Fri Dec 01 04:00:00 EST 1995 · Molecular and Cellular Biology

DOI:https://doi.org/10.1128/MCB.15.12.6702· OSTI ID:379259

Arsura, M; Deshpande, A; Sonenshein, G E ^[1]

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1. Boston Univ. School of Medicine, MA (United States); and others

This report identifies a variant form of Myc-associated factor X (Max) protein, which plays a central role in the functional activity of c-Myc as a transcriptional activator. This variation, termed dMax, lacks the basic region as well as helix 1 and loop regions as a result of alternative splicing of max mRNA. This nuclear dMax was unable to bind E-box Myc site DNA but associated with c-Myc in vitro and in vivo and repressed transactivation. 42 refs., 8 figs.

• Sponsoring Organization: USDOE
• OSTI ID: 379259
• Journal Information: Molecular and Cellular Biology, Journal Name: Molecular and Cellular Biology Journal Issue: 12 Vol. 15; ISSN 0270-7306; ISSN MCEBD4
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
AMINO ACIDS
CODONS
DNA SEQUENCING
DNA-CLONING
EXONS
FIBROBLASTS
GENE REGULATION
GENE REPRESSORS
GENES
LYMPHOCYTES
MESSENGER-RNA
MICE
MUTATIONS
NUCLEOTIDES
POLYMERASE CHAIN REACTION
PROTEINS
SPLICING
STRUCTURE-ACTIVITY RELATIONSHIPS
TRANSCRIPTION
TRANSCRIPTION FACTORS