DNA damage in freshwater mussels (Quadrula quadrula) exposed to lead and benzo[a]pyrene
Conference
·
OSTI ID:37493
- Oklahoma State University, Stillwater, OK (United States)
The sensitivities of a freshwater mussel, Quadrula quadrula, to DNA damage following sublethal exposures to two model toxicants, lead and benzo[a]pyrene (BaP), were tested. Exposures were conducted in laboratory aquaria, using a 48h static renewal protocol. Mussels wee exposed to 0 (controls), 5, 50, 500 {mu}g/L of lead (as Pb(NO{sub 3}){sub 2}) and to 0 (controls), 10, 100, and 1,000 ng/L BaP. Average DNA strand lengths were quantified in purified DNA extracts isolated from adductor muscle, foot, and mantle tissues using agarose gel electrophoresis. After the 30-day exposure to lead, DNA damage was observed in foot and adductor muscle at all exposure concentrations. DNA damage was only observed in mantle tissue at the highest BaP concentration. Tissue responses may reflect differential tissue sensitivities to DNA damage or accumulation differences for the two toxicants.
- OSTI ID:
- 37493
- Report Number(s):
- CONF-9410273--
- Country of Publication:
- United States
- Language:
- English
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