Asymmetric catalysis in supercritical carbon dioxide
- Los Alamos National Laboratory, NM (United States)
- Due Univ., Durham, NC (United States)
We are exploring the potential and utility of supercritical carbon dioxide as a reaction medium for catalytic asymmetric transformations. We will present results on the catalytic asymmetric hydrogenation of prochiral olefins, ketones, and unsaturated acids by Rh and Ru catalysts containing chiral phosphine ligands using hydrogen or hydrogen transfer agents. We have been able to effect high conversions and ee`s using hydrogen transfer systems such as HCOOH/NEt{sub 3}. We have found that asymmetric catalytic hydrogenation and hydrogen transfer reduction of enamide esters work as well or better in CO{sub 2} than in conventional solvents. We will also present the effects of reaction conditions (T, P, etc.), co-solvents and catalysts on rates and selectivities.
- OSTI ID:
- 370604
- Report Number(s):
- CONF-960376--
- Country of Publication:
- United States
- Language:
- English
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