Embryonal brain tumors and developmental control genes
Journal Article
·
· Journal of Neuropathology and Experimental Neurology
OSTI ID:369791
- Univ. Hospital, Schmelzbergstr (Switzerland)
Cell proliferation in embryogenesis and neoplastic transformation is thought to be controlled by similar sets of regulatory genes. This is certainly true for tumors of embryonic origin, such as Ewing sarcoma, Wilms` tumor and retinoblastoma, in which developmental control genes are either activated as oncogenes to promote proliferation, or are inactivated to eliminate their growth suppressing function. However, to date little is known about the genetic events underlying the pathogenesis of medulloblastoma, the most common brain tumor in children, which still carries an unfavourable prognosis. None of the common genetic alterations identified in other neuroectodermal tumors, such as mutation of the p53 gene or amplification of tyrosine kinase receptor genes, could be uncovered as key events in the formation of medulloblastoma. The identification of regulatory genes which are expressed in this pediatric brain tumor may provide an alternative approach to gain insight into the molecular aspects of tumor formation.
- OSTI ID:
- 369791
- Journal Information:
- Journal of Neuropathology and Experimental Neurology, Journal Name: Journal of Neuropathology and Experimental Neurology Vol. 54; ISSN JNENAD; ISSN 0022-3069
- Country of Publication:
- United States
- Language:
- English
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