Selenium metabolite levels in human urine after dosing selenium in different chemical forms

Journal Article · Mon Nov 01 04:00:00 EST 1993 · Bulletin of Environmental Contamination and Toxicology

DOI:https://doi.org/10.1007/BF00201655· OSTI ID:35725

Hasunuma, Ryoichi; Tsuda, Morizo; Ogawa, Tadao; Kawanishi, Yasuhiro ^[1]

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1. Kitasato Univ., Kanagawa (Japan)

It has been well known that selenium in marine fish such as tuna and swordfish protects the toxicity of methylmercury in vivo. The protective potency might depend on the chemical forms of selenium in the meat of marine fish sebastes and sperm whale. Little has been revealed, however, on the chemical forms of selenium in the meat of these animals or the selenium metabolites in urine, because the amount of the element is very scarce. Urine is the major excretory route for selenium. The chemical forms of urinary selenium may reflect the metabolism of the element. We have developed methodology for analysis of selenium-containing components in human urine. Using this method, we have observed the time courses of excretory levels of urinary selenium components after a single dose of selenium as selenious acid, selenomethionine, trimethylselenonium ion or tuna meat. 14 refs., 6 figs., 1 tab.

• Sponsoring Organization: USDOE
• OSTI ID: 35725
• Journal Information: Bulletin of Environmental Contamination and Toxicology, Journal Name: Bulletin of Environmental Contamination and Toxicology Journal Issue: 5 Vol. 51; ISSN 0007-4861; ISSN BECTA6
• Country of Publication: United States
• Language: English

Related Subjects

56 BIOLOGY AND MEDICINE
APPLIED STUDIES
BIOLOGICAL ACCUMULATION
BIOLOGICAL ADAPTATION
EVALUATION
MAN
MERCURY
METABOLITES
SELENIUM
TOXICITY
URINE