[Studies of the repair of radiation-induced genetic damage in Drosophila]. Annual progress report, 1 November 1994--1 January 1996
The authors have recently cloned the mei-4l gene, and showed that its putative translation product is highly homologous to the ATM, MEC1, and RAD3 genes at the level of primary amino acid sequence. That this sequence similarity reflects a functional homology is suggested by three lines of evidence: (1) as is the case for the ATM gene, loss of function of mei-4l results in increased sensitivity to X-irradiation; (2) mutations in the mei-4l gene also resemble ATM mutations in that they cause high levels of chromosome breakage and genetic instability; and (3) like the ATM gene, the wild-type MEI-4l protein also plays a role in mediating the progression of the cell cycle.
- Research Organization:
- Univ. of California, Dept. of Genetics, Davis, CA (United States)
- Sponsoring Organization:
- USDOE Office of Energy Research, Washington, DC (United States)
- DOE Contract Number:
- FG03-87ER60538
- OSTI ID:
- 304069
- Report Number(s):
- DOE/ER/60538--T10; ON: DE99001413
- Country of Publication:
- United States
- Language:
- English
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