[Studies of the repair of radiation-induced genetic damage in Drosophila]. Annual progress report, September 1, 1990--July 1, 1991
At this time last year, we had identified two genes in Drosophila that are required for repair of double strand breaks. These genes (mei-41 and mus302) have now been completely analyzed. We have developed an efficient system for site-directed mutagenesis using injected oligonucleotides as a template for the repair of double strand breaks. mus308, a gene responsible for resistance to DNA cross-linking, is being recovered through chromosome walking. It is believed this gene may be the Drosophila analog of the human Fanconi anemia A gene. A collaborative effort to clone the excision repair gene, mei-9, is under way. The X-ray resistance gene mus209 has been cloned. Finally, we are analyzing a group of mus mutations from other labs which we have tagged with a single transposon inserted randomly into one of the two major autosomes. 4 refs.
- Research Organization:
- California Univ., Davis, CA (United States)
- Sponsoring Organization:
- USDOE, Washington, DC (United States)
- DOE Contract Number:
- FG03-87ER60538
- OSTI ID:
- 10104847
- Report Number(s):
- DOE/ER/60538--T1; ON: DE92003768
- Country of Publication:
- United States
- Language:
- English
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[Studies of the repair of radiation-induced genetic damage in Drosophila]. Annual progress report, September 1, 1990--July 1, 1991
[Studies of the repair of radiation-induced genetic damage in Drosophila]. Annual progress report, June 1, 1989--September 1, 1990