Deciphering ApoE Genotype-Driven Proteomic and Lipidomic Alterations in Alzheimer’s Disease Across Distinct Brain Regions

Odenkirk, Melanie T.; Zheng, Xueyun; Kyle, Jennifer E.; Stratton, Kelly G.; Nicora, Carrie D.; Bloodsworth, Kent J.; Mclean, Catriona A.; Masters, Colin L.; Monroe, Matthew E.; Doecke, James D.; Smith, Richard D.; Burnum-Johnson, Kristin E.; Roberts, Blaine R.; Baker, Erin S.

doi:10.1021/acs.jproteome.3c00604

Deciphering ApoE Genotype-Driven Proteomic and Lipidomic Alterations in Alzheimer’s Disease Across Distinct Brain Regions

Journal Article · Thu Jan 18 00:00:00 EST 2024 · Journal of Proteome Research

DOI:https://doi.org/10.1021/acs.jproteome.3c00604· OSTI ID:3008511

Odenkirk, Melanie T. ^[1]; ^[2]; Kyle, Jennifer E. ^[2]; ^[2]; ^[2]; ^[2]; Mclean, Catriona A. ^[3]; Masters, Colin L. ^[4]; ^[2]; Doecke, James D. ^[5]; ^[2]; ^[2]; Roberts, Blaine R. ^[6]; ^[7]

North Carolina State University, Raleigh, NC (United States)
Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
Alfred Hospital, Prahran, VIC (Australia); University of Melbourne, VIC (Australia)
University of Melbourne, VIC (Australia)
Commonwealth Scientific and Industrial Research Organisation (CSIRO), Herston, QLD (Australia)
Emory University, Atlanta, GA (United States)
University of North Carolina, Chapel Hill, NC (United States)

Alzheimer’s disease (AD) is a neurodegenerative disease with a complex etiology influenced by confounding factors such as genetic polymorphisms, age, sex, and race. Traditionally, AD research has not prioritized these influences, resulting in dramatically skewed cohorts such as three times the number of Apolipoprotein E (APOE) e4-allele carriers in AD relative to healthy cohorts. Thus, the resulting molecular changes of AD have previously been complicated by the influence of apolipoprotein E disparities. To explore how apolipoprotein E polymorphism influences AD progression, 62 post-mortem patients consisting of 33 Alzheimer’s disease (AD) and 29 controls (Ctrl) were studied to balance the number of e4-allele carriers and facilitate a molecular comparison of the apolipoprotein E genotype. Lipid and protein perturbations were assessed across AD diagnosed brains compared to Ctrl brains, e4 allele carriers (APOE4+ for those carrying 1 or 2 e4s and APOE4- for non-e4 carriers), and differences in e3e3 and e3e4 Ctrl brains across two brain regions (frontal cortex (FCX) and cerebellum (CBM)). In conclusion, the region-specific influences of apolipoprotein E on AD mechanisms showcased mitochondrial dysfunction and cell proteostasis at the core of AD pathophysiology in the post-mortem brains, indicating these two processes may be influenced by genotypic differences and brain morphology.

View Accepted Manuscript (DOE)

Research Organization:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

Sponsoring Organization:: National Institutes of Health (NIH); USDOE Office of Science (SC), Basic Energy Sciences (BES). Scientific User Facilities (SUF)

Grant/Contract Number:: AC05-76RL01830

OSTI ID:: 3008511

Report Number(s):: PNNL-SA--193518

Journal Information:: Journal of Proteome Research, Journal Name: Journal of Proteome Research Journal Issue: 8 Vol. 23; ISSN 1535-3907; ISSN 1535-3893

Publisher:: American Chemical Society (ACS)Copyright Statement

Country of Publication:: United States

Language:: English

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Deciphering ApoE Genotype-Driven Proteomic and Lipidomic Alterations in Alzheimer’s Disease Across Distinct Brain Regions

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